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  1. WCNR Poster Abstracts,
  2. Texas Medical Center Dissertations (via ProQuest)
  3. RSSDI therapeutic wheel

Ognibene, John I. Some of the clinical project had to utilize CC resources.

Proposals had to align with the research priorities of one of the 12 supporting Institutes. A total of 74 letters of intent were submitted with 51 grant applications received. Potential investigators required assistance regarding identifying intramural partners and budget development for Clinical Center and intramural research costs. Program enhancements for the second cycle addressed these needs and included three new institute sponsors for the cycle, the implementation of a new XO2 preapplication process to facilitate the letters of support from the institutes, and creation of a new CC Website designed to facilitate communication between investigators.

Many clinical and mechanistic studies suggest that angiotensin II AII inhibition improved insulin sensitivity. Lean ZSF rats were used as controls. ZSF rats from 8th week were fed high calorie diet to maintain hyperglycemia while lean rats were fed standard diet. All rats were sacrificed at 26th week and blood and urine collected and skeletal muscle harvested for cell cultures and homogenates for protein expression. Angiotensin inhibition also increased the free fatty acid levels and improved insulin signaling by increasing adiponectin and NO levels in obese rats.

David S. Miller 2 , Yehonatan Sharabi 3, 1 , Irwin J. Kopin 1. A shift from vesicular sequestration to enzymatic oxidative deamination of cytosolic DA contributes to the low putamen DA content. Data from mice with very low activity of the type 2 vesicular monoamine transporter validated the neurochemical approach. Among 16 patients with severe NE depletion 2.

  • Maria Stuart (German Edition).
  • ESICON Abstracts.
  • RSSDI clinical practice recommendations for the management of type 2 diabetes mellitus 2017.
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  • EMBC Program | Thursday July 25, .
  • ESICON 2017 Abstracts?
  • The Man with the Bird on His Head (International Adventures).

Niewold 1. Patients from different ancestral backgrounds demonstrate differences in clinical manifestations and autoantibody profiles.

WCNR Poster Abstracts,

Differentially expressed genes DEGs were determined by comparing cases and controls of the same ancestral background. CD20 EA.

One subgroup of patients showed higher ISGs expression in all cell types, and the other subgroup had higher ISG expression only in T and B lymphocytes. AA patients. Deborah J. Fox 1, 2 , Charles E. Wade 1 , Mohammad H. Rahbar 2 , John B. Holcomb 1. Despite the advances in information and medical technologies and in research design and statistical analysis, generating valid and reproducible findings from data streaming through fire hoses remains a challenge. False hope for electronic record systems may be an 8th sin.

Effective mitigation strategies require diverse clinical, epidemiologic and statistical perspectives and vigilance. Building on the strengths of existing software tools, the Indiana CTSI created a simple solution to gathering critical data for reporting. This presentation shares how the ICTSI streamlined reporting processes to obtain real time information, monitor progress of projects, identify and respond to barriers to research, and report the outcomes from PIs awarded pilot funding.

Combining these programs with other available software, we created a process that allowed data to be shared across the ICTSI. This Pilot Grant Reporting System includes the grant application, progress reports with key outcomes, and program evaluation surveys. Progress reports can be sent to investigators within minutes and then shared with all managers of the ICTSI programs in real time as they are submitted. So, what once took hours or days to input the data into a usable format for reporting now can be done within minutes.

Additionally, because the process is an interweaving of software, each part can be modified as needed by any program or CTSA. Most importantly, these tools, used as a single system, allow us to provide current information to stakeholders on demand. Eight diverse health Facebook pages were selected to represent a target population of those people interested in health. A random sample was taken over a six month duration. Third, it creates interdisciplinary bridges for future research by blending research in leadership, social science, psychology, linguistics, communication, consumerism, and healthcare.

However, a key challenge is management and integration of online content to ensure its usefulness and impact. We used these three domains to classify our existing extensive ITHS online content. We believe our work exemplifies a best practice of research training and faculty development within and across organizations, and a model that could be adopted both by CTSAs.

Plain language training deserves consideration as a strategy for helping translational researchers communicate more clearly with communities and study participants—helping boost engagement and dissemination efforts. Georgeanna F. Robinson 1 , Lisa S. Schwartz 1 , Linda A.

Texas Medical Center Dissertations (via ProQuest)

Dimeglio 2 , Jasjit S. Ahluwalia 3 , Janice L. Gabrilove 4. Institutional and professional factors important for facilitating independent funding included: mentors who were generous with time, advice, networks and resources; protected time for research; and a strong community of researchers in a similar content area or discipline. Personal facilitators included resilience, initiative to steer one's career, autonomy, and building one's research network.

Lack of any of these factors was a barrier to transitioning. Resources were provided e. Six domains were identified. Subgroups defined competencies in each domain. Drafts were compiled and refined by MICHR staff into competency statements which were further refined by the advisory group. Aliyah R. Snyder 1 , Joe M. Gullett 1 , David B.

FitzGerald 2 , Russell M. Bauer 1, 2. Loss of consciousness LOC accompanying head injury predicts atrophy, and repetitive injury has an additive effect on cognitive dysfunction and neuropathological burden. Objectives: to examine the impact of LOC on brain volume and characterize the relationship of brain volume changes postinjury with cognitive functioning. Veterans were divided into groups based on number of sustained LOC. Brain volume and LOC were not related to executive performance.

Therapeutic interventions targeting the OC methylome reverse drug resistance and induce clinical responses. A major challenge in studying DUF has been acquiring accurate copy number estimates of domain subtypes clades.

RSSDI therapeutic wheel

The objectives of this study were to acquire accurate DUF domain copy number measurements, identify the normal spectrum of copy number variation in a healthy population and determine the association of copy number with neurodevelopmental and neuropsychiatric phenotypes. Case samples were obtained from Baylor College of Medicine and Rutgers University while control samples were obtained from Rutgers University and the Coriell Institute. All samples were obtained with IRB approval. Multiple phenotype associations with DUF copy number were identified. These include a novel association with autism severity and confirmation of an association with brain size.

These data also highlight the relevance of this gene family to autism severity and suggest an integral role in neurodevelopment. Future research will continue to determine the association between DUF copy number and neurocognitive function and dysfunction. Melittin is a cell lytic peptide that has shown promise in glioblastoma treatment. Protein therapeutics are prone to aggregation and degradation: both processes leading to inactivation of the molecule.

Hydrogels have shown promise in protecting proteins, but modes of reversible protein attachment to hydrogels are lacking. Inhibitory neurotransmission is altered in patients with epilepsy. The mice were allowed to recover and their hippocampi were collected at 6, 24, 48, 72 hrs, 1 and 16 weeks after injury. We were also able to generate epileptic mice 10 weeks after TBI. Future studies will determine if blocking this pathway with WP alters the development of epilepsy after experimental TBI.

LV and LA volumes and function were assessed by echocardiography and cardiac magnetic resonance imaging. LV and LA pressure volume relationships PVR, admittance catheter were recorded 8 weeks postsurgery and tissue sections were obtained for histological analyses fibrosis and cell size. LA stroke volume and active emptying fraction were higher while the proportional contribution of LA conduit function to LV stroke volume was reduced. Our results also demonstrate decreased LA compliance and suggest less efficient atrial compensation may occur at higher filling pressures.

Jeffrey M. Grabowski 1 , Rushika Perera 2 , Ali M. Roumani 3, 1 , Victoria Hedrick 1 , Halina D.